In late 2001 the I30 got its most significant host of upgrades, including styling changes, minor revisions to the interior, new optional equipment, larger brakes, a re-tuned suspension system, a standard traction control system, and optional electronic stability control. The updated model was renamed " Infiniti I35" to reflect an engine displacement increase from 3.0 to 3.5 liters, with the new VQ35DE V6, producing 255 hp (190 kW).
In September 2004, Nissan announced that I35 production would cease and that model year 2004 would be the last for this vehicle. It was also the last remaining front-wheel drive Infiniti since the G20 ended production after the 2002 model year. Infiniti discontinued the I after a short run of 2004 models, replaced by the new Infiniti M which had been introduced earlier for the 2003 model year.